1. Update the map of data set with Build37 Shifman genetic map and save the new file as "Li2008_C3HxB6_B37_Data.csv". The file is ready to be read into Rqtl; 2. Generate a description file of the project, it includes the general information, definitions of phenotypes, description of genotypes and information of missing markers; 3. For the genotypes of this cross: (cM=centimorgan, bp=basepair) (1) Change the missing values from "0" to "-" in B37 data file; (2) Change small "dmit" into big "DMit" and correct typo errors among all markers; (3) Nine markers missed bp positions in Shifman genetic map, assign the position from current MGI database. This type of markers are highlighted with orange color and please see description file for details; (4) Marker "D1Mit406", "D7Mit71" and "D18Mit34" missed bp position in both Shifman map and MGI database. Primer sequences found in MGI, and their locations identified using primer-BLAST in NCBI followed by UCSC In-Silico PCR (it is highlighted with green color in description file); (5) The bp positions of marker "D3Mit19" and "D14Mit185" missed in both Shifman map and MGI. Primer sequences found in MGI, but their locations didn't match the result from primer-BLAST in NCBI. We could not identify the B37 bp position of these markers currently (they are highlighted with pink color in description file); (6) Marker "D13Mit63" was on chr 13 in original data file, but the result from converted tool mapped it on chr 4; I checked MGI database and found the marker was on chr 13 so we kept it on chr 13, Use the bp position found in MGI and converted it to cM through Map Converter tool (marker is highlighted with yellow color in description file); (7) Potential genotyping errors are detected when the dataset is loaded into R/qtl. Specifically, 43 ̉CÓ genotypes are observed on the X chromosome in females from the cross (B6xC3H)x(B6xC3H), they are treated as missing values if I use Rqtl to do data analysis. 4. For the phenotypes of the cross: (1) Change the missing values "x" into "-" in B37 data file; (2) Add a column name "mouse ID" into the 1st column of phenotypes (it doesn't have title in original file); (3) Add a column of "sex" into the B37 data file (241 female mice in total, this information is provided by paper); (4) Add a column of pgm into the B37 data file (the direction of the cross is (B6xC3H)F1 x (B6xC3H)F1 and the information is found in paper); (5) The unit of body weight is not found in paper (highlight in blue color); 5. Except the "csv" file mentioned above, I also saved the description file, original data, data with B37 map, working record and list of missing markers together as a big excel file ("Data_Description_C3HxB6_Li2008.xls") (first curation work was finished on 8/7/2009, files updated on 8/25/2009, 12/7/2010). 6. Information updated on 11/9/2011: (1) Changed the name of the map (from "Shifman" to "Cox" map) in description and readme file, add a map reference in description file; (3) Generate genetic map plot, missing genotypes plot, map comparison plot, whole genome RF plot and problematic chromosome RF plots for B37 data. The last marker on chr 6 had correlation with the last marker on chr 7, markers on chr 12 and 15 had order problems (observed from RF plot). All quality control plots were saved in "QCReport_Li2008.pdf".